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标题：SIRT4 regulates ATP homeostasis and mediates a retrograde signaling via AMPK
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作者：Linh Ho ; Allen Sam Titus ; Kushal Kr Banerjee 等
期刊名称：Aging
出版年度：2013
卷号：5
期号：11
页码：835-849
出版社：U.S.Department of Health & Human Service
摘要：Efficient. coupling. of. cellular. energy. production. to. metabolic. demand. is. crucial. to. maintain. organismalhomeostasis..Here,. we. report. that.the. mitochondrial. Sirtuin. Sirt4. regulates.mitochondrial.ATP.homeostasis..We. find.thatSirt4.affects. mitochondrial.uncoupling. via.the. adenine. nucleotide. translocator.2. (ANT2).. Loss.of.Sirt4. expression.leads. todecreased. cellular. ATP. levels. in. vitro. and. in. vivo. while. Sirt4. overexpression. is. associated. with. increased. ATP. levels.Further,. we. provide. evidence. that. lack. of. Sirt4. activates. a. retrograde. signaling. response. from. the. mitochondria. to. thenucleus.that.includes.AMPK,.PGC1¦Á,.key.regulators.of.¦Â©\oxidation.such.as.Acetyl©\CoA.carboxylase,.and.components.of.themitochondrial. respiratory. machinery.. This. study. highlights. the. ability. of. Sirt4. to. regulate. ATP. levels. via. ANT2. and. afeedback.loop.involving.AMPK