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标题：Relationships between human vitality and mitochondrial respiratory parameters, reactive oxygen species production and dNTP levels in peripheral blood mononuclear cells
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作者：Scott Maynard ; Guido Keijzers ; Martin Gram 等
期刊名称：Aging
出版年度：2013
卷号：5
期号：11
页码：850-864
出版社：U.S.Department of Health & Human Service
摘要：Low.vitality. (a.component.of.fatigue).in.middle©\aged.and.older.adults.is.an.important.complaint.often. identifiedas. a. symptom. of. a. disease. state. or. side. effect. of. a. treatment.. No. studies. to. date. have. investigated. the. potential. linkbetween. dysfunctional. mitochondrial. ATP. production. and. low. vitality.. Therefore,. we. measured. a. number. of. cellularparameters. related. to. mitochondrial. activity. in. peripheral. blood. mononuclear. cells. (PBMCs). isolated. from. middle©\agedmen,. and. tested. for. association. with. vitality.. These. parameters. estimate. mitochondrial. respiration,. reactive. oxygenspecies. (ROS). production,. and. deoxyribonucleotide. (dNTP). balance. in. PBMCs.. The. population. was. drawn. from. theMetropolit. cohort.of.men.born.in.1953..Vitality. level. was.estimated.from.the. Medical.Outcomes.Study.Short.Form.36.(SF©\36). vitality. scale.. We. found. that. vitality. score. had.no. association. with. any. of. the. mitochondrial. respiration. parameters.However,. vitality. score. was. inversely. associated. with. cellular. ROS. production. and. cellular. deoxythymidine. triphosphate(dTTP). levels. and. positively. associated. with. deoxycytidine. triphosphate. (dCTP). levels.. We. conclude. that. self©\reporte dpersistent. low. vitality. is. not. associated. with. specific. aspects. of. mitochondrial. oxidative. phosphorylation. capacity. inPBMCs,. but. may. have. other. underlying. cellular. dysfunctions. that. contribute. to. dNTP. imbalance. and. altered. ROSproduction
关键词：vitality;.mitochondrial.respiration;.reactive.oxygen.species;.deoxyribonucleotides