In this paper a technique to control virus concentration for HIV-1 infection model obtained from actual patients data is introduced. The strategy is based on Linear quadratic regulator (LQR) and applied for each patient. Feedback linearization is also presented and preferred over other methods like the Taylor series, due to the fact that approximation around an operating point may not perform satisfactorily. The proposed controller has the ability to control the dynamic behavior of the virus concentration for different patients with the same control design. In addition, controller performance of both short and long term periods for each patient is evaluated.