The critical power of OTAs has attracted special attention to how much they contribute to the online travel industry in general. It is crucially important for both OTAs and hotels to grasp the necessity of engaging in partnerships with each other and benefit from the win-win scenario. In light of these, this study aims to examine how OTAs contribute to the profitability and performance of hotels by investigating: cost reductions experienced by hotels working with OTAs, revenue enhancements experienced by hotels working with OTAs, and overall improvements in the businesses of hotels working with OTAs. The study has been conducted with a sample of 92 hotels in Turkey since working with both local and international OTAs is a rapidly increasing trend among hotels. This diffusion is crucial since Turkey is a country with a very large potential for both domestic and international tourists and reaching a wide customer base is much more efficient and effective through the use of OTAs. Findings show that the most important contribution of working with OTAs for hotels is increasing sales and competition power, increasing revenues from standard hotel services, and improving brand and customer power.