摘要：Evolutionarily conserved signaling pathways and transcription factors that sense physiological and environmental states regulate aging processes. Lifespan extension was achieved by the modulation of these pathways in yeast, worms, flies and mice. Remarkably, slowing aging processes resulted in the amelioration of age-dependent degenerative diseases (reviewed by Kenyon, Nature, 2010, 464: 504). Our recent study (Oh, PNAS, 2013, 110: 19024) shows that lifespan-extending signaling pathways may provide opportunities for therapeutic interventions of muscle degenerative diseases
