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标题：Transposable elements become active and mobile in the genomes of aging mammalian somatic tissues
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作者：Marco De Cecco ; Steven W. Criscione ; Abigail L. Peterson 等
期刊名称：Aging
出版年度：2013
卷号：5
期号：12
页码：867-883
出版社：U.S.Department of Health & Human Service
摘要：Transposable. elements. (TEs).were. discovered.by. Barbara.McClintock. in. maize. and. have. since. been. found.to. beubiquitous. in. all. living. organisms.. Transposition. is. mutagenic. and. organisms. have. evolved. mechanisms. to. repress. theactivity. of. their. endogenous. TEs.. Transposition. in. somatic. cells. is. very. low,. but. recent. evidence. suggests. that. it. may. bederepressed. in. some. cases,. such. as. cancer. development.. We. have. found. that. during. normal. aging. several. families. ofretrotransposable. elements.(RTEs). start.being.transcribed. in.mouse.tissues.. In. advanced.age.the.expression.culminates.inactive. transposition.. These. processes.are. counteracted. by. calorie. restriction.(CR),.an. intervention. that.slows. down.aging.Retrotransposition. is. also.activated. in. age©\associated,. naturally. occurring. cancers.in.the. mouse..We. suggest. that. somaticretrotransposition. is.a.hitherto.unappreciated.aging.process..Mobilization.of.RTEs. is. likely.to.be. an. important.contributorto.the.progressive.dysfunction.of.aging.cells
关键词：Aging;.epigenetics;.chromatin;.transposable.elements