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标题：Functional metagenomic profiling of intestinal microbiome in extreme ageing
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作者：Simone Rampelli ; Marco Candela ; Silvia Turroni 等
期刊名称：Aging
出版年度：2013
卷号：5
期号：12
页码：902-912
出版社：U.S.Department of Health & Human Service
摘要：Age©\related. alterations. in. human. gut. microbiota. composition. have. been. thoroughly. described,. but. a. detailedfunctional.description.of.the.intestinal.bacterial.coding.capacity.is.still.missing..In.order.to.elucidate.the.contribution.of.thegut.metagenome.to.the.complex.mosaic.of.human.longevity,.we.applied.shotgun.sequencing.to.total.fecal.bacterial.DNA.ina.selection.of.samples.belonging.to.a.well©\characterized.human.ageing.cohort..The.age©\related.trajectory.of.the.human.gutmicrobiome. was. characterized. by. loss. of. genes. for. shortchain. fatty. acid. production. and. an. overall. decrease. in. thesaccharolytic. potential,. while. proteolytic. functions. were. more. abundant. than. in. the. intestinal. metagenome. of. youngeradults..This. altered. functional. profile.was.associated.with.a.relevant. enrichment.in."pathobionts",.i.e..opportunistic. pro©\inflammatory.bacteria.generally.present.in.the.adult. gut.ecosystem. in.low.numbers..Finally,.as.a.signature.for.long.life.weidentified. 116.microbial. genes. that. significantly. correlated. with.ageing.. Collectively,. our.data. emphasize.the. relationshipbetween.intestinal.bacteria.and.human.metabolism,.by.detailing.the.modifications.in.the.gut.microbiota.as.a.consequenceof.and/or.promoter.of.the.physiological.changes.occurring.in.the.human.host.upon.ageing
关键词：centenarians;.extreme©\aging;.gut.microbiome