摘要:Introduction: The number of diabetics has progressively increased in recent decades. Pain is reported as one of the main complaints of these patients. On the other hand, in case of resistance exercises, there is no sufficient evidence on pain relief. Accordingly, the purpose of this study was to investigate the effect of resistance exercise on pain threshold and blood pressure in patients with diabetes mellitus. Methods: 11 overweight diabetic male patients (45-50 years) were selected through purposeful random sampling, but 3 of them refused to continue collaboration. After measuring one repetition maximum (1RM) , they completed three sets of strength exercise with intensity of 80% 1RM. Pain threshold and blood pressure was measured by special devices in active arm and finally data were analyzed using paired t-test and the correlation coefficient. Results: Increased pain threshold and diastolic and systolic blood pressure was observed immediately after the resistance exercise (P≤0.05) , but the relationship between diastolic blood pressure and pain threshold was not significant. Conclusions: The results revealed contrast interaction between blood pressure and pain threshold that suggests the central mechanisms of pain may engage in diabetic people