In order to extend the pump inspection cycle of the seriously-eccentric-wear well, FU-4 water-based lubricant, which can lubricate the boundary and form chemical reaction film and chemical adsorption film on the tubing and pump sucker rods surface, is synthesized by using water-based lubrication theory for reference which has been widely applied in the fields of cutting, grinding and others fields. The chemical reaction film and chemical adsorption film formed by the response activity of phosphorus, nitrogen and fatty acid molecules in the system for the carrier function have good abrasion resistance and anti-friction performance as well as good biodegradability. Adding water-based lubricant of 0.025% to 0.05% in the wells routine maintenance may extend the pump inspection cycle of eccentric-wear side grinding wells. It provides referable technique for managing side grinding wells.