The present paper endeavors to trace the sketch of a possible epistemology of the human sciences. In this sense it begins with the determination of the object of knowledge in the human sciences through a careful examination of the reality of history and of the human world. Then, considering the peculiarity of the domain of the human sciences the paper proceeds to show that their object of knowledge is best understood as “event” in the sense of Gilles Deleuze and Alain Badiou. And, in the end, it circumscribes two modes of knowledge of this object of the human sciences understood as event.