期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2013
卷号：110
期号：52
页码：E5059-E5068
DOI：10.1073/pnas.1320862110
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：SignificanceApolipoprotein E-/- (ApoE-/-) mice deficient in nucleotide binding oligomerization domain-containing protein 2 (NOD2) and subjected to an oral gavage of Porphyromonas gingivalis developed elevated serum inflammatory cytokines, cholesterol, alveolar bone loss, and atherosclerosis. Stimulation of NOD2 by Muramyl DiPeptide (MDP) in ApoE-/- mice reduced P. gingivalis-induced inflammatory cytokines, cholesterol, alveolar bone loss, and atherosclerosis by reducing the expression of inhibitor of NF-{kappa}B kinase-{beta
