期刊名称：Annals of Agricultural and Environmental Medicine
印刷版ISSN：1232-1966
电子版ISSN：1898-2263
出版年度：2012
卷号：19
期号：4
页码：711-716
出版社：Institute of Agricultural Medicine in Lublin
摘要：Introduction and Objective: Dental caries is an in ammatory disease with multifactorial etiology. The presented study was conducted to test the hypothesis that the elevation of salivary cytokines – interleukin- 6 (IL-6), interleukin-8 (IL-8) and tumour necrosis factor (TNF-a) is changed in dental caries patients. IL-6, IL-8 and TNF-a are particularly relevant to in ammation, one of the very rst responses of the host to a pathological insult.Materials and Methods: Whole saliva from 26 patients with dental caries, as well as 10 healthy persons, was investigated for the presence of IL-6, IL-8 and TNF-a by enzyme immunoassay – ELISA.Results: The results showed that an elevation of IL-6, IL-8 and TNF-a in unstimulated whole saliva in subjects with dental caries, compared with controls, increased and was statistically signi cant in all cases (p <0.05). The study also show a positive correlation between TNF-a an d IL- 8.Conclusions: These data suggest links between the production of tumour necrosis factor (TNF-a), interleukin-6 (IL-6), interleukin-8 (IL-8) in saliva and dental caries disease
关键词：dental c aries; saliva; interleukin-6; interleukin-8; tumour necrosis factor a; in ammation
