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  • 标题:Pro-inflammatory cytokines in saliva of adolescents with dental caries disease
  • 本地全文:下载
  • 作者:Agnieszka Gornowicz ; Anna Bielawska ; Krzysztof Bielawski
  • 期刊名称:Annals of Agricultural and Environmental Medicine
  • 印刷版ISSN:1232-1966
  • 电子版ISSN:1898-2263
  • 出版年度:2012
  • 卷号:19
  • 期号:4
  • 页码:711-716
  • 出版社:Institute of Agricultural Medicine in Lublin
  • 摘要:Introduction and Objective: Dental caries is an in ammatory disease with multifactorial etiology. The presented study was conducted to test the hypothesis that the elevation of salivary cytokines – interleukin- 6 (IL-6), interleukin-8 (IL-8) and tumour necrosis factor (TNF-a) is changed in dental caries patients. IL-6, IL-8 and TNF-a are particularly relevant to in ammation, one of the very rst responses of the host to a pathological insult.Materials and Methods: Whole saliva from 26 patients with dental caries, as well as 10 healthy persons, was investigated for the presence of IL-6, IL-8 and TNF-a by enzyme immunoassay – ELISA.Results: The results showed that an elevation of IL-6, IL-8 and TNF-a in unstimulated whole saliva in subjects with dental caries, compared with controls, increased and was statistically signi cant in all cases (p <0.05). The study also show a positive correlation between TNF-a an d IL- 8.Conclusions: These data suggest links between the production of tumour necrosis factor (TNF-a), interleukin-6 (IL-6), interleukin-8 (IL-8) in saliva and dental caries disease
  • 关键词:dental c aries; saliva; interleukin-6; interleukin-8; tumour necrosis factor a; in ammation
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