期刊名称：Annals of Agricultural and Environmental Medicine
印刷版ISSN：1232-1966
电子版ISSN：1898-2263
出版年度：2012
卷号：19
期号：4
页码：842-845
出版社：Institute of Agricultural Medicine in Lublin
摘要：Introduction. The discordance between glycated hemoglobin (HbA1C) and fruc tosamine (FA) estimations in the assessment of glycemia is of ten encountered. A number of mechanisms might explain such discordance, but whether or not they are consistent is uncertain. Nevertheless, the fac t that there is a discrepancy in HbA1Cand mean blood glucose cannot be ignored in the monitoring of glycemic control. To address the discrepancy between HbA1Cand mean blood glucose, Robert Cohen proposed the measurement of glycation gap (GG). Recently, the 'Glycation Gap' (GG) has been de ned as the di erence between the measured HbA1C. GG has improved the quality of the monitoring of glycemic control, especially for those patients whose HbA1Clevels do not truly re ect the mean blood glucose levels.Objective: The aims of the statistical analyses were to estimate GG values in a healthy subject. The research was conducted among the inhabitants of the Zwierzyniec commune and nearby villages. Material and methods: The study population consisted of 93 subjects: 63 women and 30 men, between the ages of 18-79. Measurements of HbA1Cand FA in the 93 people were used to calculate GG, de ned as the di erence between measured HbA1Cand HbA1Cpredicted from FA, based on the population regression of HbA1Co n FA .Conclusions: In considering the values GG in the study group, particular signi cance should be attributed to a progressive increase of GG with advancing age. Elderly people who are at risk of developing diabetes, or who have already developed the disease, may not exhibit the classic symptoms expec ted. Age-related changes can mean that some symptoms will be masked, or more di cult to spot. It is worth pointing out that HbA1Ctogether with GG must be taken into account in the correct interpretation of the glycation processes
关键词：fructosamine; glycated hemoglobin; glycation gap
