期刊名称：Annals of Agricultural and Environmental Medicine
印刷版ISSN：1232-1966
电子版ISSN：1898-2263
出版年度：2013
卷号：20
期号：1
页码：116-121
出版社：Institute of Agricultural Medicine in Lublin
摘要：Introduction: Type 2 diabetes is associated with an increased risk of some types of cancer. Diabetes treatment may also modif y cancer risk.Objective: The aim of this retrospective, case-control study was to assess whether HbA1clevel and use of anti-diabetic drugs are associated with cancer development in a diabetic population.Materials and methods: The case group consisted of 53 patients who developed cancer after diagnosis of diabetes. They were compared with 53 diabetic subjects without cancer, strictly matched to a case group by age and gender. In both groups – apart from HbA1cand diabetes treatment – demographic data, smoking habits, comorbidities, BMI, diabetes duration, use of aspirin, antihypertensive and hypolipemic drugs were also analyzed.Results: Patients with cancer had a significantly higher mean HbA1cvalue compared with the control group, 7.83±1.26% vs. 7.30±1.08%, respec tively (p= 0.022). The distribution of patients in four HbA1ccategories (<7.0, 7.0-7.9, 8.0-8.9 and ≥9.0%) was significantly different between the two groups (p=0.031). The probability of cancer was higher among patients with HbA1cvalue ≥8.0 % OR 3.160 (95% CI 1.342-7.440), p=0.013, and lower among patients using metformin, OR 0.228 (95% CI 0.083-0.633), p= 0.006. The number of insulin users, insulin dose, duration of insulin treatment, and use of other anti-diabetic drugs were not significantly different between the two groups. Also, no significant differences were found between the two groups regarding other variables.Conclusions: The presented case-control study indicated an important role of metabolic control and confirmed the protective role of metformin in reducing cancer risk among patients with type 2 diabetes. Contrary to other studies, insulin use was not associated with a higher risk of cancer. Other anti-diabetic drugs appeared to have a neutral impac t on cancer development.
