文章基本信息

标题：A cross-sectional assessment of oxidative DNA damage and muscle strength among elderly people living in the community
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作者：Basilua Andre Muzembo ; Yasunori Nagano ; Masamitsu Eitoku 等
期刊名称：Environmental Health and Preventive Medicine
印刷版ISSN：1342-078X
电子版ISSN：1347-4715
出版年度：2014
卷号：19
期号：1
页码：21-29
DOI：10.1007/s12199-013-0350-x
出版社：Springer Japan
摘要：Objectives
The mechanism by which muscle weakness leads to an increased risk of death remains a subject of interest. In this context, the aim of this study is to assess the relationship between urinary 8-hydroxy-2′-deoxyguanosine (8-OHdG) and muscle strength, and other risk factors contributing to poor muscle strength in older persons.
Methods
This was a cross-sectional study in which a total of 86 participants, both men and women, aged 65 years or above were screened for urinary 8-OHdG, and muscle strength as measured by handgrip strength.
Results
Handgrip strength was lower in participants who had history of acute or chronic disease. Urinary 8-OHdG level was negatively associated with muscle strength, and the association remained after adjusting for confounding factors.
Conclusions
Urinary 8-OHdG is associated with muscle strength. These findings may be clinically relevant as there is a possibility of controlling oxidative DNA damage by healthy behaviors related to lifestyle.
关键词：Oxidative stress; Handgrip strength; Cross-sectional study; Older persons; Lifestyle;