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  • 标题:Variants of mouse DNA polymerase κ reveal a mechanism of efficient and accurate translesion synthesis past a benzo[a]pyrene dG adduct
  • 本地全文:下载
  • 作者:Yang Liu ; Yeran Yang ; Tie-Shan Tang
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:2014
  • 卷号:111
  • 期号:5
  • 页码:1789-1794
  • DOI:10.1073/pnas.1324168111
  • 语种:English
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:DNA polymerase {kappa} (Pol{kappa}) is the only known Y-family DNA polymerase that bypasses the 10S (+)-trans-anti-benzo[a]pyrene diol epoxide (BPDE)-N2-deoxyguanine adducts efficiently and accurately. The unique features of Pol{kappa
  • 关键词:translesion DNA synthesis ; polycyclic aromatic hydrocarbons
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