期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2014
卷号：111
期号：6
页码：2391-2396
DOI：10.1073/pnas.1323433111
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：The digital nature of genes combined with the associated low copy numbers of proteins regulating them is a significant source of stochasticity, which affects the phase of biochemical oscillations. We show that unlike ordinary chemical oscillators, the dichotomic molecular noise of gene state switching in gene oscillators affects the stochastic dephasing in a way that may not always be captured by phenomenological limit cycle-based models. Through simulations of a realistic model of the NF{kappa}B/I{kappa}B network, we also illustrate the dephasing phenomena that are important for reconciling single-cell and population-based experiments on gene oscillators.
