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  • 标题:Flavonoids: Antioxidants Against Atherosclerosis
  • 本地全文:下载
  • 作者:Davide Grassi ; Giovambattista Desideri ; Claudio Ferri
  • 期刊名称:Nutrients
  • 电子版ISSN:2072-6643
  • 出版年度:2010
  • 卷号:2
  • 期号:8
  • 页码:889-902
  • DOI:10.3390/nu2080889
  • 语种:English
  • 出版社:MDPI Publishing
  • 摘要:Oxidative stress results from an imbalance between excessive formation of reactive oxygen species (ROS) and/or reactive nitrogen species and limited antioxidant defences. Endothelium and nitric oxide (NO) are key regulators of vascular health. NO bioavailability is modulated by ROS that degrade NO, uncouple NO synthase, and inhibit synthesis. Cardiovascular risk conditions contribute to oxidative stress, causing an imbalance between NO and ROS, with a relative decrease in NO bioavailability. Dietary flavonoids represent a range of polyphenolic compounds naturally occurring in plant foods. Flavonoids are potentially involved in cardiovascular prevention mainly by decreasing oxidative stress and increasing NO bioavailability.
  • 关键词:oxidative stress; endothelial dysfunction; atherosclerosis; antioxidants; flavonoids
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