摘要：The Adverse Drug Reactions Advisory Committee (ADRAC) database collates notifications of adverseevents following immunisation (AEFI) from across Australia. The data were analysed for vaccinesreceived between 1 January 2000 and 30 September 2002. Dose-based AEFI reporting rates werecalculated using denominator data from the Australian Childhood Immunisation Register and annualnational influenza vaccination coverage surveys. The majority of the 2,409 AEFI records analyseddescribed non-serious events, principally injection site reactions; 10.5 per cent (n=253) described AEFIswith outcomes defined as 'serious'. Ten deaths were recorded but only one, following yellow fevervaccine, was causally related to immunisation. The average annual population-based reporting rate was4.5 per 100,000 population. Vaccine dose-based AEFI reporting rates were 2.2 per 100,000 doses ofinfluenza vaccine for adults aged 40 years and over and 14.6 per 100,000 doses of all scheduled vaccinesfor children aged less than 7 years. The most frequently reported type of adverse event was injection sitereaction following receipt of an acellular pertussis-containing vaccine, particularly among children inthe age groups scheduled to receive their fourth or fifth doses of the vaccine (overall reporting rate 67 per100,000 doses). The data highlight the safety of vaccines in Australia, and illustrate both the utility ofavailable immunisation coverage data to estimate dose-based AEFI reporting rates and the value of theADRAC database as a surveillance tool for monitoring AEFIs nationally.
