摘要：Two hundred and forty-fi ve human in. uenza A and B viruses isolated in Australia between 1996 and 2003 were tested for their sensitivity to the NA inhibitor drugs, zanamivir and oseltamivir using a . uorescence-based neuraminidase inhibition assay. Based on mean IC50values, in. uenza A viruses (with neuraminidase subtypes N1 and N2) were more sensitive to both the NA inhibitors than were in. uenza B strains. In. uenza A viruses with a N1 subtype and in. uenza B strains both demonstrated a greater sensitivity to zanamivir than to oseltamivir carboxylate, whereas in. uenza A strains with a N2 subtype were more susceptible to oseltamivir carboxylate. A comparison of IC50values for viruses isolated before and after the release of the NA inhibitors in Australia, found there was no signifi cant difference in the sensitivity of strains to either neuraminidase inhibitor and none of the isolates tested showed clinically signifi cant resistance
关键词：i n. uenza; neuraminidase inhibitors; oseltamivir carboxylate; zanamivir; Australia
