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  • 标题:PDGFRβ reverses EphB4 signaling in alveolar rhabdomyosarcoma
  • 本地全文:下载
  • 作者:M. Imran Aslam ; Jinu Abraham ; Atiya Mansoor
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:2014
  • 卷号:111
  • 期号:17
  • 页码:6383-6388
  • DOI:10.1073/pnas.1403608111
  • 语种:English
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:Alveolar rhabdomyosarcoma (aRMS) is an aggressive myogenic childhood malignancy, not infrequently presenting as incurable metastatic disease. To identify therapeutic targets, we performed an unbiased tyrosine kinome RNA interference screen in primary cell cultures from a genetically engineered, conditional mouse model of aRMS. We identified ephrin receptor B4 (EphB4) as a target that is widely expressed in human aRMS and that portends a poor clinical outcome in an expression level-dependent manner. We also uncovered cross-talk of this ephrin receptor with another receptor tyrosine kinase, PDGFR{beta
  • 关键词:sarcoma ; pediatric ; muscle
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