摘要：Helicobacter pylori (H. pylori) induces gastroduodenal diseases and vigorous humural and cellular immune abnormalities. In
order to clarify the immunological changes before and after eradication of H. pylori,
the percentages and ratios of the following cells in the peripheral blood of 32 H. pylori-infected patients and 25 control subjects were analyzed:
CD4+ T cells, CD8+ T cells, T helper 1 cells (Th1), T helper 2 cells (Th2),
CD4+CD25+ T cells, Foxp3+ regulatory T cells (Treg), CD4/CD8 ratio, and
Th1/Th2 ratio. CD4/CD8 ratio was significantly higher in H. pylori-infected
patients before (mean ± SD, 2.9 ± 1.9) and after (mean ± SD, 2.8 ± 1.6) eradication of H. pylori than in control
subjects (mean ± SD, 2.1 ± 0.9). The percentage of Th2 cells was significantly higher in H. pylori-infected
patients (mean ± SD, 2.6 ± 1.1) than
in control subjects (mean ± SD, 1.9 ± 1.1; p H. pylori (mean ± SD, 2.3 ± 1.4) was lower
than that before eradication. There was no significant difference between
control subjects (mean ± SD, 4.1% ± 1.5%) and patients before H. pylori eradication (mean ± SD, 4.5% ± 2.4%) in the percentage of Tregs, but the
percentage was significantly higher in patients
after H. pylori eradication (mean ± SD, 5.2% ±2.6%) than in control
subjects. The function of peripheral induced Tregs was reported to suppress the excessive
immune reaction in chronic inflammation. These data suggest that Tregs may
proliferate and be activated to suppress the activation of humoral immunity in H. pylori-infected patients, and
these changes continue after 3 months or later of successful eradication of H. pylori.
关键词：<i>Helicobacter pylori</i>; Regulatory T Cell; Th1 Cell; Th2 Cell
