摘要：Objectives: To determine the effect of rotavirus vaccination on rotavirus hospitalisations in children under 5 years of age at The Canberra Hospital, Australian Capital Territory.Methods: Rotavirus hospitalisations in children under 5 years of age at the Canberra Hospital were identified through a retrospective clinical audit of electronic medical hospitalisations in the pre-vac-cine (2004–2006) and post-vaccine (2008–2012) periods. Records and confirmation with rotavirus pathology results were compared using MS Excel and Stata.Results: Laboratory confirmed rotavirus infections resulted in 289 children being admitted to the Canberra Hospital between January 2004 and December 2012. Hospitalisation for rotavirus gas-troenteritis decreased by 76% in the 5 years follow-ing vaccine introduction compared with pre-vac-cine periods. Seasonal patterns of hospitalisation were prominent in pre-vaccine periods but were attenuated post-vaccine. The greatest decreases in hospitalisation between pre– and post-vaccine periods were observed in the 12–23 (80%) and 24–35 (88%) month age categories. Decreases in hospitalisation were reported for patients unlikely to have received vaccine cover at that time, indicating an indirect protective effect of rotavirus vaccine.Conclusions: This study reports significant reduc-tions in rotavirus hospitalisation of children under 5 years of age at The Canberra Hospital following vaccine introduction, mid-2007. These findings sup-port rotavirus vaccination as an effective measure to reduce hospitalisation in children under 5 years of age.
