This paper examined the moderating of strategy communication, focusing on the influence of organizational structure and organizational culture on the performance of the higher educational Institutions in Palestine. The study generated a quantitative questionnaire data from 255 respondents representing the top, medium and low management level of the higher educational institutions in Palestine. Data were analyzed using the partial least squares-Structural equation model PLS-SEM. Overall, the findings revealed that organizational structure and organizational culture are significantly related to the performance of higher educational institutions in Palestine. A Further result of the moderating role showed that strategy communication failed to moderate the influence of both organizational structure and organizational culture on the organizational performance. Discussions on the findings, implication and limitation of the study were also provided.