This study examines the relationship between law enforcement work-related stressors and health issues. Specifically, this study attempts to determine the effects of stress-producing factors (e.g. vigorous activities at work, shift change, perceived danger associated with police work, etc.) on physiological health-related issues (e.g. the number of reported health issues, high blood pressure, back pain, and headaches) and psychosocial behavior problems (e.g. alcohol consumption and cigarette smoking) among police officers. The analyses are based on a total 1632 law enforcement officers, who represent 51 police agencies in the three major cities, New York City, Dallas Texas, and Minneapolis, USA. The research findings that emerged from this study show that the number of days in vigorous activities and perceived physiological demands have the strongest influence on the number of health-related issues. Working without a partner and frequent shift changes had the strongest influence on alcohol consumption by police officers.