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  • 标题:Bovine β-lactoglobulin/fatty acid complexes: binding, structural, and biological properties
  • 本地全文:下载
  • 作者:Solène Le Maux ; Saïd Bouhallab ; Linda Giblin
  • 期刊名称:Dairy Science & Technology
  • 印刷版ISSN:1958-5586
  • 电子版ISSN:1958-5594
  • 出版年度:2014
  • 卷号:94
  • 期号:5
  • 页码:409-426
  • DOI:10.1007/s13594-014-0160-y
  • 语种:English
  • 出版社:EDP Sciences
  • 摘要:

    Ligand-binding properties of β-lactoglobulin (β-lg) are well documented, but the subsequent biological functions are still unclear. Focusing on fatty acids/β-lg complexes, the structure-function relationships are reviewed in the light of the structural state of the protein (native versus non-native aggregated proteins). After a brief description of β-lg native structure, the review takes an interest in the binding properties of native β-lg (localization of binding sites, stoichiometry, and affinity) and the way the interaction affects the biological properties of the protein and the ligand. The binding properties of non-native aggregated forms of β-lg that are classically generated during industrial processing are also related. Structural changes modify the stoichiometry and the affinity of β-lg for fatty acids and consequently the biological functions of the complex. Finally, the fatty acid-binding properties of other whey proteins (α-lactalbumin, bovine serum albumin) and some biological properties of the complexes are also addressed. These proteins affect β-lg/fatty acids complex in whey given their competition with β-lg for fatty acids.

  • 关键词:Bovine β-lactoglobulin ;Fatty acid ;Binding properties ;Biological properties ;Protein structure
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