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  • 标题:Elucidating the Role of Neurotensin in the Pathophysiology and Management of Major Mental Disorders
  • 本地全文:下载
  • 作者:Mona M Boules ; Paul Fredrickson ; Amber M Muehlmann
  • 期刊名称:Behavioral Sciences
  • 电子版ISSN:2076-328X
  • 出版年度:2014
  • 卷号:4
  • 期号:2
  • 页码:125-153
  • DOI:10.3390/bs4020125
  • 语种:English
  • 出版社:MDPI Publishing
  • 摘要:Neurotensin (NT) is a neuropeptide that is closely associated with, and is thought to modulate, dopaminergic and other neurotransmitter systems involved in the pathophysiology of various mental disorders. This review outlines data implicating NT in the pathophysiology and management of major mental disorders such as schizophrenia, drug addiction, and autism. The data suggest that NT receptor analogs have the potential to be used as novel therapeutic agents acting through modulation of neurotransmitter systems dys-regulated in these disorders.
  • 关键词:neurotensin; schizophrenia; antipsychotic drugs; addiction; autism spectrum disorder; animal models
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