The article presents legal and political aspects of the Strategy of prevention of and protection against discrimination. This is a binding commitment from the state given to its citizens in relation to reaching certain goals, principally towards eliminating discrimination in social life. The main aim of the presentation is to highlight factors which are necessary to ensure the Strategy is efficient in combating a culture of intolerance; in identifying what is necessary in practice to tackle discrimination, particularly discrimination against unpopular groups; so that a culture of intolerance among state agencies and organizations of civil society would be replaced by culture of mutual respect and equal opportunities. The article considers all categories that may be protected against discrimination, such as women, LGBT persons, people with disabilities, Roma people, elderly people, children, refugees, national minorities, internally displaced persons and people whose health condition might be the ground of discrimination. [Projekat Ministarstva nauke Republike Srbije: br. III 47010: Društvene transformacije u procesu evropskih integracija - multidisciplinarni pristup]