Reverse supply chain is a cycle of recovery for the products and materials used by the customers but can be returned to the chain performing some operations. Due to significance of reverse supply chain in the content of environmental and economical aspects, we formulate a mathematical model of reverse multi-layer multi-product supply chain for minimizing the total costs including returning, disassembly, processing, recycling, remanufacturing, and distribution centers. The presented model is an integer linear programming model being solved using Lingo 9 software. Numerical experiments are conducted to gain insight into the proposed model. The solutions provide a decision aid stream strengthening the concept of reverse supply network design and analysis for profit-making organization.