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  • 标题:Testing the Assumption of Non-differential Misclassification in Case-Control Studies
  • 本地全文:下载
  • 作者:Lee, Tze-San ; Hui, Qin
  • 期刊名称:Journal of Modern Applied Statistical Methods
  • 出版年度:2013
  • 卷号:12
  • 期号:2
  • 页码:12
  • 出版社:Wayne State University
  • 摘要:One of the not yet solved issues regarding the misclassification in case-control studies is whether the misclassification rates are the same for both cases and controls. Currently, a common practice is to assume that the rates are the same, that is, the non-differential misclassification assumption. However, it has been suspected that this assumption may not be valid in practical applications. Unfortunately, no test is available so far to test the validity of the non-differential misclassification assumption. A method is presented to test the validity of non-differential misclassification assumption in case-control studies with 2 × 2 tables when validation data are not available. First, a theory of exposure operating characteristic curve is developed. Next, two non-parametric methods are presented to test the assumption of non-differential misclassification. Three real-data sets taken from practical applications are used as examples to illustrate the methods.
  • 关键词:Exposure operating characteristic (EOC) curve; non-differential misclassification; sensitivity; specificity; Youden’s index
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