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  • 标题:Methylphenidate enhances neural stem cell differentiation
  • 本地全文:下载
  • 作者:Jasmin Bartl ; Takatoshi Mori ; Peter Riederer
  • 期刊名称:Journal of Molecular Psychiatry
  • 印刷版ISSN:2049-9256
  • 出版年度:2013
  • 卷号:1
  • 期号:1
  • 页码:5
  • DOI:10.1186/2049-9256-1-5
  • 语种:English
  • 出版社:BioMed Central
  • 摘要:The psychostimulant methylphenidate (MPH) is the first choice of drug treatment in Attention-Deficit/Hyperactivity Disorder (ADHD). Since therapy often begins at a time when the brain is still developing and the long-term consequences of MPH are still not fully clarified, we examined the influences of an acute treatment with MPH on the differentiation and proliferation of murine neural stem cells (mNSC). We found that MPH enhanced neuronal differentiation and inhibited neural proliferation.
  • 关键词:Methylphenidate ; Neural stem cells ; Neuronal maturation ; Cell proliferation
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