Many studies have suggested that cardiovascular and respiratory disease mortality may change with fluctuations in temperature. In this study the relation between temperature and mortality has been studied in a city with desert climate. Four years data on daily temperature, cardiovascular, respiratory mortality and air pollution was acquired for Kerman, Iran. Time series, regression and correlation analyses were performed. Results showed an inverse relationship between mortality and temperature in Kerman, in which decreases in temperature were associated with increases in mortality. This pattern is similar to some foreign studies which show acclimatization of people living in southern warmer climates and less negative effects of warm temperatures. Among the pollutants only dust (p=0.003) and SO2 (p<0.001) showed a positive correlation with respiratory mortality.