期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2014
卷号：111
期号：49
页码：17576-17581
DOI：10.1073/pnas.1420936111
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：SignificanceThe T-cell receptor (TCR) does not signal on its own. Instead, it is constitutively associated with the CD3 coreceptors, which contain intracellular signaling motifs. Although antigen (Ag) recognition by the TCR and the activation of T cells after CD3 activation have been extensively studied, there is far less known about how the TCR relays the binding of Ag to initiate intracellular signaling. Detailed study of the eight-chain TCR-CD3 complex is hampered by limited structural information for how the components of the complex interact. We use complementary structural approaches to examine where the TCR-CD3 extracellular domains are placed relative to each other and the overall organization of the complex. {beta} T-cell receptor (TCR) activation plays a crucial role for T-cell function. However, the TCR itself does not possess signaling domains. Instead, the TCR is noncovalently coupled to a conserved multisubunit signaling apparatus, the CD3 complex, that comprises the CD3{varepsilon}{gamma
关键词：T-cell receptor ; electron microscopy ; small-angle X-ray scattering
