期刊名称：International Journal of Computer Science and Security (IJCSS)
电子版ISSN：1985-1553
出版年度：2008
卷号：2
期号：5
页码：1-5
出版社：Computer Science Journals
摘要：Phylogenies are the main tool for representing the relationship among biological entities. Phylogenetic reconstruction methods attempt to find the evolutionary history of given set of species. This history is usually described by an edgeweighted tree, where edges correspond to different branches of evolution, and the weight of an edge corresponds to the amount of evolutionary change on that particular branch. Phylogenetic tree is constructed based on multiple sequence alignment, but sometimes alignment fails if the data set is large and complex. In this paper a new distance matrix is proposed to reconstruct phylogenetic tree. The pair-wise scores of input sequences were transformed to distance matrix by Feng Doolittle formula before solved by neighbor-joining algorithm. Two data sets were tested with the algorithm: BChE sequences of mammals, BChE sequences of bacteria. We compared the performance and tree of our result with ClustalX and found to be similar.
关键词：Phylogeny; Bioinformatics; Distance matrix; Phylogenetic tree; neighbor-joining algorithm; Clustal X
