The incidence of infertility is approximately 15–20% (one in every five to six couples). The investigation of the infertile couple begins with a careful history, followed by a physical examination. If any abnormality is observed in the history, the couple must be referred. The principle of evaluation of the infertile couple is to establish if the female is ovulatory or anovulatory. If ovulatory, the couple must be referred for more detailed examinations. If anovulatory and her prolactin and TSH as well as his semen analysis are normal, ovulation induction with a low dose of clomiphene citrate can be offered. On the other hand, if her prolactin and TSH as well as his semen analysis are abnormal, it is best to refer the patient.