Climate change that has occurred at the end of the last and at the beginning of this century, among other things, has a certain impact on forests as well. For the territory of Eastern Serbia, for two periods of climate observations, the reference period 1961-1990 and the period 1991-2012, a comparative analysis of the following climatic elements was done: air temperature, amount of precipitation and relative humidity of air. Calculations were performed on the basis of collected and systematized data from 11 meteorological stations (6 synoptic/main climatological and 5 regular climatological) that were part of the Republic Hydrometeorological Service, situated in the area of Eastern Serbia. Analysis of the anomalies of air temperature and precipitation as indicators of climate change for the period 1991-2012 compared to the reference period 1961-1990 was done separately for each of the four seasons (winter, spring, summer, autumn) and summarized for each period. The results of the comparative analysis show that in the period 1991-2012 compared to the reference period 1961-1990, there was an increase in the average annual air temperature, as well as the increase in the average air temperature for all four seasons, and a decrease in the average annual amounts of precipitation and the decrease in the relative humidity of air. [Projekat Ministarstva nauke Republike Srbije, br. 37008]