出版社：International Medical Journal Management and Indexing System
摘要：Introduction: Duloxetine is a dual acting antidepressant (selective serotonin and norepinephrine reuptake inhibitor). Existing data suggest that the advisable therapeutic serum level of duloxetine ranges between 20 and 80 ng/mL. This study aimed to evaluate pharmacokinetics of oral duloxetine used in a dose range of 30-90 mg/day. 12 Methods: In a naturalistic setting we determined duloxetine serum levels within a steady state in a sample of depressive outpatients by liquid chromatography mass spectrometry (LC/MS). Patients received flexible duloxetine doses of 30-90 mg once daily, with dose changes made based on clinical improvement and tolerability. The study population consisted of 60 females and 53 males. Plasma duloxetine levels were assayed on the 7th-180th day of treatment, 24 hour after the last dose. Results: Smokers showed a considerably higher dosage of duloxetine, but their serum level of duloxetine was not differed from nonsmoking group. Body weight and age did not significantly affect duloxetine pharmacokinetic parameters. Conclusion: This research suggests that therapeutic response is not associated with serum levels of duloxetine. However, compared to nonsmokers, smokers require higher doses. Key words: duloxetine, serum level, clinical response, smoking
