出版社：International Medical Journal Management and Indexing System
摘要：Several studies suggest that memory suppression in humans occur as an active process of executive control, mediated by regions of prefrontal cortex, which is a substrate for ovarian hormones. However the effect of ovarian hormones on this process is not known. In order to address this question, we utilized the quantitative analysis of ovarian hormones in combination with think (T) /no think (NT) paradigm in a within-subject design study. We compared the rate of memory control between the follicular (low estrogen and progesteron) and mid-luteal (high estrogen and progesteron) phases of regularly cycling healthy women. Our data demonstrate that during midluteal phase, 63.6 % of subjects are able to suppress or actively forget (significantly less % recall below the baseline) previously learned word pairs in the NT condition; i.e., not to think the target word associated with the cue word. However during the follicular phase there was no effect of NT condition on the active forgeting of word pairs below the baseline as assesed by the memory test applied after the T/NT procedure. Thus, our results indicate the modulatory effect of ovarian hormones during the process of active forgetting.
关键词：Memory suppression; Estrogen; Executive control
