出版社：International Medical Journal Management and Indexing System
摘要：Acute Decompensated Heart Failure is a major reason for the admission of heart failure patients to the clinics and every attack increases the mortality and the morbidity of the patients. Loop diuretics are the most frequently-used drugs in acute decompansated heart faiure, but they have been proven to be related with several unwanted results such as electrolyte imbalance, renal dysfunction and increased mortality. In recent years, ultrafiltration has gained an interest as an alternative to the diuretic treatment and several randomized clinical studies comparing the diuretic treatment and ultrafiltration have been conducted. One of the most comprehensive studies on this issue is UNLOAD (Ultrafiltration versus Intravenous Diuretics for Patients Hospitalized for Acute Decompensated Heart Failure), in which higher weight loss 48 hours after the treatment and fewer hospitalizations in a 90-day follow-up period were observed in the ultrafiltration group. In CARRESS-HF (Cardiorenal Rescue Study in Acute Decompensated Heart Failure), diuretic treatment is considered to be superior over ultrafiltration in terms of the protection of renal functions in the 96th hour. It is, however, noteworthy that these studies have many limitations about the ultrafiltration rate, duration and frequency. Therefore new and better designed data are required on this issue.
