摘要：The n-hexane is widely used in the production of glues, lacquers, paints, plastic and rubber products. Therefore, a significant potential for exposure to this toxic solvent exists in industrial settings. This study was carried out to assess the individual exposure of workers to n-hexane and their urinary concentration of free 2, 5-hexanedione were determined. Thirty-eight male workers from 6 shoe making workshops were studied. Individual exposure of workers to n-hexane and their urinary concentration of free 2, 5-hexanedione were determined. Data were analyzed using the SPSS/PC statistical package version 16.0. The calculated time-weighted average exposure to n-hexane and the average urinary concentration of free 2, 5-hexanedione were estimated to be 76.8 mg m-3 and 0.241 mg L-1, respectively. A good correlation (r = 0.815) was found between time-weighted average exposure to n-hexane and urinary levels of free 2, 5-hexanedione. Significantly higher urinary concentrations of free 2, 5-hexanedione detected in subjects who did not wear gloves. Our data indicate that workers average exposure to n-hexane and the levels of free 2, 5-hexanedione in their urine did not exceed the current proposed threshold limit value and biological exposure index for this chemical. Additionally, our findings provide further evidence in favor of the notion that free 2, 5-hexanedione is an appropriate indicator for biological monitoring of workers exposed to n-hexane. Finally, it is implied that dermal exposure also plays an important role in the overall absorption of n-hexane by the human body.
