Antiphospholipid syndrome (APS) is defined by hypercoagulability and pregnancy morbidity occuring in the presence of antiphospholipid antibodies. APS occurs as an isolated , primary condition or be associated with a connective tissue disease such as systemic lupus erythematosus (SLE). Anesthesiologists could encounter these patients in the intensive care unit in thrombotic crisis, in routine surgery or high-risk parturients, so information on peri-operative management be required. We present a case of general anesthesia for a patient with APS associated with SLE and chronic renal failure.