文章基本信息
- 标题：Effectiveness of Ondansetron and Midazolam in the Prevention of PONV after Thyroidectomy
- 本地全文：下载
- 作者：Ha, Jae Hyun ; Kwak, Kyung Hwa ; Seo, Jeong Won 等
- 期刊名称：Korean Journal of Anesthesiology
- 印刷版ISSN：2005-6419
- 出版年度：2007
- 卷号：53
- 期号：3
- 页码：344-349
- DOI：10.4097/kjae.2007.53.3.344
- 语种：Korean
- 出版社：The Korean Society of Anesthesiologists,
- 摘要：Background
The purpose of this study was to investigate the effectiveness of ondansetron and midazolam in the prevention of PONV after thyroidectomy.
MethodsOne hundred nineteen women undergoing thyroidectomy under general anesthesia were randomized to receive midazolam 0.075 mg/kg (Group M, n = 41), ondansetron 4 mg (Group O, n = 39), or normal saline 10 ml (Group C, n = 39) intravenously. The incidence and severity of nausea, vomiting, and pain were assessed as 6 and 24 h after the end of surgery.
ResultsThe incidence of PONV was 34% in Group M, 46% in Group O, and 64% in Group C, which showed a significant difference between Group C and Group M, but not Group O. However, there were no significant differences between groups in pain scores and the incidence of sedation.
ConclusionsWe recommend the use of midazolam as an effective antiemetic after thyroidectomy.
- 关键词：antiemetic; ondansetron; Midazolam; postoperative nausea and vomiting (PONV); thyroidectomy
