Guillain-Barre syndrome (GBS) is an acute demyelinating polyneuropathy, associated with symmetrical muscle weakness, areflexia, and ascending paralysis. Although it has been reported during all the three trimesters of pregnancy and in the post-partum period, the occurrence of GBS in the third trimester presents a high maternal risk because of respiratory complications and the risk of premature delivery. We report the successful anesthetic management of a parturient with GBS.