Moderate to severe pulmonary hypertension, mean pulmonary arterial pressure (mPAP) > 35 mmHg, in cirrhotic patients is usually considered an absolute contraindication to orthotopic liver transplantation (OLT) because of unacceptably high mortality. We present the case of successful OLT in a cirrhotic patient with a mPAP of 42 mmHg and a pulmonary vascular resistance (PVR) of 298 dyne·sec·cm^-5 preoperatively. He was treated with oral sildenafil (Viagra®) and inhaled iloprost (Ventavis®) for 45 days and then his mPAP and PVR were reduced to 33 mmHg and 206 dyne·sec·cm^-5 at the time of transplantation. During OLT, his mPAP was stable of 28-38 mmHg with the combined use of sildenafil via a nasogastric tube and iloprost via a nebulizer. His hemodynamic parameters were stable and significant postoperative bleeding was not noticed throughout his stay in the intensive care unit. Thereafter, he was transferred to general ward without any cardio-respiratory problems on 7th postoperative days.