Sudden hearing loss is a rare complication after general anesthesia. The variety of etiologies and the difficulty in treatment must be a challenge to anesthesiologists. In this patient who was otherwise normal in her right ear, sudden sensorineural hearing loss occurred immediately after general anesthesia. The possible causes of her sensorinerual hearing loss we supposed are the inner ear dysfunction by drilling noise or the pressure change of middle ear cavity or the microvascular circulatory deficiency related to head-rotated position. After steroid, prostaglandin injection and stellate ganglion block therapy, remarkable improvement of hearing was observed.