Complex regional pain syndrome (CRPS) is characterized by pain, sensory, motor and autonomic symptoms. But its pathophysiological mechanisms are unclear and CRPS is quite difficult to comprehend and treat. The diagnostic criteria for CRPS at this time are purely clinical, and the use of diagnostic tests has not been demonstrated, so that misdiagnosis of CRPS is not uncommon. We report a case misdiagnosed CRPS which is due to the complication of one level total cervical disc replacement, which was treated successfully with reoperation.