In a patient with diabetes mellitus undergoing continuous ambulatory peritoneal dialysis with icodextrin, icodextrin is partially absorbed via lymphatics into the systemic circulation and its metabolites may affect the enzymatic glucose determinations used in many bedside glucometers (using glucose dehydrogenase-based method). This leads to erroneously elevated glucose levels. We report a severe hypoglycemia due to falsely elevated capillary blood glucose levels in a patient with diabetes mellitus undergoing continuous ambulatory peritoneal dialysis with icodextrin during general anesthesia.