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  • 标题:Effect of a single dose of esmolol on the bispectral index to endotracheal intubation during desflurane anesthesia
  • 本地全文:下载
  • 作者:Choi, Eun Mi ; Min, Kyeong Tae ; Lee, Jeong Rim
  • 期刊名称:Korean Journal of Anesthesiology
  • 印刷版ISSN:2005-6419
  • 出版年度:2013
  • 卷号:64
  • 期号:5
  • 页码:420-425
  • DOI:10.4097/kjae.2013.64.5.420
  • 语种:English
  • 出版社:The Korean Society of Anesthesiologists,
  • 摘要:Background

    In this prospective, randomized, double-blind, placebo-controlled trial, we investigated the effect of a single dose of esmolol on the bispectral index (BIS) to endotracheal intubation during desflurane anesthesia.

    Methods

    After induction of anesthesia, 60 patients were mask-ventilated with desflurane (end-tidal 1 minimum alveolar concentration) for 5 min and then received either normal saline, esmolol 0.5 or 1 mg/kg, 1 min prior to intubation (control, esmolol-0.5 and esmolol-1 groups, n = 20/group). BIS, mean arterial pressure, and heart rate were measured prior to anesthesia induction and esmolol administration, immediately preceding intubation (time point 0), and every minute for 5 min after intubation (time point 1 to 5). At time point 0, 1 and 5, 5 ml of arterial blood was taken to measure plasma concentrations of norepinephrine and epinephrine.

    Results

    BIS increased significantly at 1 min after intubation when compared with pre-intubation values in all groups. Both mean arterial pressure and heart rate increased significantly 1 min after intubation when compared with preintubation values for all groups. Plasma epinephrine concentrations did not increase significantly after tracheal intubation in any of the groups. Norepinephrine increased at 1 min after intubation when compared with the preintubation values in the esmolol groups (P < 0.05).

    Conclusions

    A single bolus of esmolol was unable to blunt the increase in BIS to endotracheal intubation during desflurane anesthesia.

  • 关键词:bispectral index; desflurane; esmolol; Intubation; norepinephrine
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