文章基本信息

标题：Effect of Bevacizumab on Survival and Production of Nitric Oxide in Trabecular Meshwork Cells
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作者：Kim, Sin Hoo ; Kim, Jae Woo
期刊名称：Journal of the Korean Ophthalmological Society
印刷版ISSN：0378-6471
出版年度：2009
卷号：50
期号：9
页码：1404-1408
DOI：10.3341/jkos.2009.50.9.1404
语种：Korean
出版社：The Korean Ophthalmological Society
摘要：Purpose
To investigate the effect of bevacizumab, a monoclonal antibody against vascular endothelial growth factor (VEGF), on the survival and production of nitric oxide (NO) in human trabecular meshwork cells (HTMC).
Methods
Primarily cultured HTMC were exposed to 0, 0.25, 1.0, and 2.5 mg/ml bevacizumab for 24 hours. Cellular survival and production of NO were assessed by MTT assay and Griess assay, respectively.
Results
Bevacizumab did not affect the cellular survival at low concentrations but decreased cellular survival significantly at high concentrations (>1.0 mg/ml) accompanied with increased NO production.
Conclusions
High concentrations of bevacizumab may be toxic to HTMC.
关键词：Bevacizumab; Nitric Oxide; Trabecular meshwork cells