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  • 标题:Effect of Hormone Replacement Therapy on Dry Eye Syndrome in Postmenopausal Women: A Prospective Study
  • 本地全文:下载
  • 作者:Moon, Jung Hyun ; Jung, Jee Woong ; Shin, Kyung Hwan
  • 期刊名称:Journal of the Korean Ophthalmological Society
  • 印刷版ISSN:0378-6471
  • 出版年度:2010
  • 卷号:51
  • 期号:2
  • 页码:175-179
  • DOI:10.3341/jkos.2010.51.2.175
  • 语种:Korean
  • 出版社:The Korean Ophthalmological Society
  • 摘要:Purpose

    To evaluate the effects of conjugated hormone replacement therapy (HRT) on dry eye syndrome in postmenopausal women.

    Methods

    Thirty-six healthy postmenopausal women (72 eyes) were included in this three-month prospective study. Schirmer test, tear film break-up time (BUT), fluorescein staining score and symptom score were performed on all patients at the time of enrollment, one month and three months after initiation of HRT. All patients received HRT consisting of conjugated estrogen and progesterone taken orally in a continuous combined regimen.

    Results

    Symptom score significantly decreased from 2.10±0.79 before HRT to 1.32±0.84 after one month and to 0.88±0.67 after three months ( p <0.001). In addition, tear film BUT measurements significantly increased from 6.04±2.54 seconds to 7.99±2.43 seconds after one month and to 8.93±2.20 after three months ( p <0.001). The fluorescein staining score was 0.94±0.71 before HRT and decreased to 0.42±0.60 after one month and to 0.22±0.42 after three months ( p <0.001).

    Conclusions

    Hormone replacement therapy consisting of conjugated estrogen and progesterone significantly improved the symptoms and signs of dry eye syndrome in postmenopausal women.

  • 关键词:Dry eye syndrome; Hormone replacement therapy; Postmenopausal woman
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